Contents

Research Areas

Functional Material Design - Nannoparticles​ (NPs)

 

Synthesis and functionalization of nanoparticles, particularly magnetic nanoparticles, for applications in therapeutics, tissue engineering, imaging, targeted drug delivery, and hyperthermia, with a focus on surface modification, advanced characterization, and biological evaluation of biocompatible multifunctional nanomaterials.

Cancer Treatment and Biomedical Applications

Innovative approaches to cancer treatment using magnetic hyperthermia, gene therapy, and innovative nanoparticle systems.

Metal stress and metal-dependent cell death pathways involving dysregulated ion homeostasis, oxidative damage, and activation of programmed death mechanisms.

3-Dimensional Cell Culture

Advanced  3-dimensional cell culture using magnetic nanoparticles, spheroid formation techniques, and advanced tissue engineering systems.

Molecular Mechanisms

Biochemical analysis of cellular stress responses, oxidative stress, and signaling pathways.

  • Laser Scanning Confocal Microscopy
  • Flow Cytometry

Papers

After 2025

  1. Başbüyük, E. B., Akyüz, M., Solak, K., & Kara, A. (2026). Doxorubicin-loaded chitosan–silver nanocarrier elicits chemoresistance in liver cancer cells. Medical Oncology, 43(9), 245.

  2. Arslan, S. Y., Turhan, F., Solak, K., Karabulut, H., Sisecioglu, M., & Unver, Y. (2026). A New Strategy of Alternating Current Magnetic Field‐Assisted Three‐Phase Partitioning (ACMF‐TPP) for the Concentration and Partial Purification of Recombinant Prepromelittin Produced by Komagataella phaffii. Biotechnology and Applied Biochemistry.

  3. Aksoy, H. R., Solak, K., MAVI, A., & Nadaroglu, H. Magnetic Hyperthermic and Anticancer Properties of Hydrothermally Synthesized Magnetic Nanoparticles Using Gypsophila. Journal of Magnetism and Magnetic Materials. 636, 173639 .https://doi.org/10.1016/j.jmmm.2025.173639

  4. Solak, K., Mavi, A., Taghizadehghalehjoughi, A., Yildirim, S., Genç, S., & Hacımüftüoğlu, A. (2025). Enhanced antitumor effects of interferon-stimulating DNA and magnetic hyperthermia in a breast cancer rat model. Journal of Drug Delivery Science and Technology, 110, 103933. https://doi.org/10.1016/j.jddst.2025.103933

  5. Dagci, I., Arslan, S. Y., Solak, K., Acar, M., Ünver, Y., & Mavi, A. (2025). Methanol-free protein expression in Komagataella phaffii with magnetic or non-magnetic heating. Microbial Biotechnology, 18(6), 1–13. https://doi.org/10.1111/1751-7915.13850

  6. Solak, K., Arslan, S. Y., Acar, M., Turhan, F., Ünver, Y., & Mavi, A. (2025). Combination of magnetic hyperthermia and gene therapy for breast cancer. Apoptosis, 30(1–2), 99–116. https://doi.org/10.1007/s10495-024-01890-2

  7. Solak, K., Atiş, M., Kasapoğlu, A. E., Karaman, A., & Mavi, A. (2025). Metal nanoparticles for simultaneous use in AC magnetic field hyperthermia and magnetic resonance imaging. Journal of Biomedical Materials Research – Part A, 113(1), 145–160. https://doi.org/10.1002/jbm.a.37425

Before 2025
  1. Dagci, I., Solak, K., Oncer, N., Yildiz Arslan, S., Unver, Y., Yilmaz, M., et al. (2024). Machine learning-assisted SERS reveals the biochemical signature of enhanced protein secretion from surface-modified magnetic nanoparticles. ACS Applied Materials & Interfaces, 16(51), 70392–70406. https://doi.org/10.1021/acsami.4c20000
  2. Güney, B. N., Kızıloğlu, H. T., Solak, K., Ulusoy, D., & Kara, A. (2024). Investigation of the Effects of Metformin and Ifosfamide Applications on Cell Proliferation and Apoptosis in Hepatocellular Carcinoma Cells. Eurasian Journal of Molecular and Biochemical Sciences, 3(1), 17-24.
  3. Firat, C., Öztürk, A., Dağcı, İ., Ünver, Y., & Solak, K. (2024). NanoScript: A Novel Tool for Gene Regulation Based on Nanoparticles with Benefits and Drawbacks. Eurasian Journal of Molecular and Biochemical Sciences, 3(1), 30-36.
  4. Sancaktutan, Ş., İspahi, B., Arslan, Ş. Y., Solak, K., & Ünver, Y. (2024). Magnetofection: A Magical Technique for Effective Gene Transfer Using Magnetic Nanoparticles. Eurasian Journal of Molecular and Biochemical Sciences, 3(1), 25-29.
  5. Kalakenger, S., Arslan, S. Y., Turhan, F., Acar, M., Solak, K., Mavi, A., et al. (2024). Heterologous expression of codon-optimized azurin transferred by magnetofection method in MCF-10A cells. Molecular Biotechnology, 66(6), 1434–1445. https://doi.org/10.1007/s12033-024-00800-0
  6. Gul, R., Muhammad, N., Sirajuddin, M., Noor, A., Tumanov, N., Wouters, J., et al. (2024). Design, physicochemical confirmation, single crystal structures as well as exploration of antibacterial and anticancer potential of organotin(IV) carboxylates. Journal of Molecular Structure, 1300, 131–145. https://doi.org/10.1016/j.molstruc.2024.131045
  7. Celik, S., Solak, K., & Mavi, A. (2023). Sulfanilamide modified magnetic nanoparticles for purification of carbonic anhydrase from bovine blood. Applied Biochemistry and Biotechnology, 195(6), 3900–3913. https://doi.org/10.1007/s12010-023-04325-x
  8. Acar, M., Solak, K., Yildiz, S., Ünver, Y., & Mavi, A. (2022). Comparative heating efficiency and cytotoxicity of magnetic silica nanoparticles for magnetic hyperthermia treatment on human breast cancer cells. 3 Biotech, 12(11), 421. https://doi.org/10.1007/s13205-022-03315-1
  9. Kim, H., Solak, K., Han, Y., Cho, Y., Koo, K., Kim, C., et al. (2022). Electrically controlled mRNA delivery using a polypyrrole-graphene oxide hybrid film to promote osteogenic differentiation of human mesenchymal stem cells. Nano Research, 15(10), 9253–9263. https://doi.org/10.1007/s12274-022-4545-9
  10. Muhammad, N., Ahmad, M., Sirajuddin, M., Ali, Z., Tumanov, N., Wouters, J., et al. (2022). Synthesis, characterization, biological activity and molecular docking studies of novel organotin(IV) carboxylates. Frontiers in Pharmacology, 13, 987654. https://doi.org/10.3389/fphar.2022.987654
  11. Yildiz, S., Solak, K., Acar, M., Mavi, A., & Ünver, Y. (2021). Magnetic nanoparticle mediated-gene delivery for simpler and more effective transformation of Pichia pastoris. Nanoscale Advances, 3, 4482–4491. https://doi.org/10.1039/D1NA00354H
  12. Solak, K., Mavi, A., & Yilmaz, B. (2021). Disulfiram-loaded functionalized magnetic nanoparticles combined with copper and sodium nitroprusside in breast cancer cells. Materials Science & Engineering C-Materials for Biological Applications, 119, 111700. https://doi.org/10.1016/j.msec.2020.111700
  13. Chafik, A., Essamadi, A., Çelik, S. Y., Solak, K., & Mavi, A. (2019). Characterization of an interesting selenium-dependent glutathione peroxidase (Se-GPx) protecting cells against environmental stress: The Camelus dromedarius erythrocytes Se-GPx. Biocatalysis and Agricultural Biotechnology, 18, 101000.
  14. Cakmak, K., BAYRAM, Ö., SOLAK, K., KABAN, G., ŞİMŞEK, Ö., & Mavi, A. (2019). Plasma polymerized linalool (ppLin): an antimicrobial and biocompatible coating. Turkish Journal of Chemistry, 43(1), 323-334.
  15. Celik, H., Aydin, T., Solak, K., Khalid, S., & Farooqi, A. A. (2018). Curcumin on the “flying carpets” to modulate different signal transduction cascades in cancers: next‐generation approach to bridge translational gaps. Journal of cellular biochemistry, 119(6), 4293-4303.
  16. Chafik, A., Essamadi, A., Çelik, S. Y., Solak, K., & Mavi, A. (2018). Partial purification and some interesting properties of glutathione peroxidase from liver of camel (Camelus dromedarius). Russian Journal of Bioorganic Chemistry, 44(1), 41-51.
  17. Solak, K., Mavi, A., Ergon, T., Sezen, A., & Algur, Ö. F. (2017). Nanomaterials and the microbial sphere. Nanoscience and Nanotechnology Letters, 9(5), 609-623.